Potency Biomarker Effect of Endothelial Microparticles (EMPs) for Early Prediction of Cardiovascular Risk in Shift Worker Nurses

Abstract

Objectives. Shift work results in changing worker’s behavior, food, and sleep patterns, which can cause circadian rhythm disturbance, which is a cardiovascular risk. Until now, a biomarker of early prediction of cardiovascular risk on shift workers is still not developed. This study aimed to assess the cardiovascular risk of shift worker nurses by detecting endothelial microparticles (EMPs).

Methods. This longitudinal study compared six shift nurses and five non-shift nurses by measuring the EMPs using antigen CD31+ flow cytometry. All met the inclusion criteria consisting of 28 blood samples followed in one week shift.

Results. EMPs among non-shift nurses were below 200 μL. However, shift nurses’ EMPs increased above 200 μL with Man-Whitney U p = 0.000 on days 4 and 7 following a one shift per week schedule.

Conclusion. There was an increase in shift workers’ endothelial microparticles (EMP) which was a sign of cardio-vascular risk.