Association of Homocysteine Levels to Traditional Risk Factors in Unstable Angina and Non-ST Elevation Myocardial Infarction: Implications from the FINEST study

  • Jose B. Nevado Jr.
  • Marcelo Severino B. Imasa
Keywords: homocysteine, risk factors, unstable angina, myocardial infarction

Abstract

Background: Increased blood homocysteine level is a risk factor for unstable angina and non-ST elevation myocardial infarction (NSTEMI).

Studies associate homocysteine levels with conventional cardiovascular risk factors - smoking, diabetes, hypertension, advanced age,

and dyslipidemia – in subjects with evidence of having coronary artery disease.

Objective: This study seeks to determine the effect of conventional cardiovascular risk factors on homocysteine levels of patients with

intermediate to high-risk unstable angina and non ST elevation myocardial infarction (NSTEMI).

Results: Data were taken from 219 patients with unstable angina and non ST elevation myocardial infarction (NSTEMI) with onset within

the past two weeks and who were included in a folic acid supplementation trial (ISRCTN30249553). Using univariate analysis, baseline

homocysteine levels are positively correlated with age (p=0.008) and significant smoking history, both current and past (p=0.028), but

negatively correlated with body mass index (BMI) (p=<0.001). No significant association was detected with diabetes mellitus, hypertension,

dyslipidemia and sex.

Conclusion: Homocysteine levels increase with age and smoking, but decrease with BMI, in patients with unstable angina and NSTEMI.

Published
2008-12-02
How to Cite
1.
Nevado Jr. JB, Imasa MSB. Association of Homocysteine Levels to Traditional Risk Factors in Unstable Angina and Non-ST Elevation Myocardial Infarction: Implications from the FINEST study. Acta Med Philipp [Internet]. 2008Dec.2 [cited 2024Mar.28];42(1). Available from: https://actamedicaphilippina.upm.edu.ph/index.php/acta/article/view/2368
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