Bullous Systemic Lupus Erythematosus and Membranous Lupus Nephritis in a Filipino Child

  • Marc Andrew O. Perez
  • Candice B. Brillante
  • Lourdes Paula R. Resontoc
  • Dolores D. Bonzon
  • Francisco E. Anacleto
  • Eric T. Aragon
  • Cherica A. Tee
  • Sherbeth Mae M. Rey
  • Georgina C. Pastorfide
  • Cybill Dianne C. Uy
  • Jolene Kristine G. Gatmaitan
Keywords: Systemic lupus erythematosus, child, membranous lupus nephritis, vesiculobullous, bullous lupus


Bullous eruptions are rare cutaneous manifestations of systemic lupus erythematosus. We report a case of an 8-year old Filipino girl with vesiculobullous systemic lupus erythematosus (SLE) and membranous lupus nephritis on kidney biopsy who presented with clinical nephrotic features of generalized edema, proteinuria, hypoalbuminemia and hyperlipidemia. The 2012 Systemic Lupus International Collaborating Clinics (SLICC) classification criteria for SLE were met. Immunohistopathologic examination of the skin lesion revealed a sub-epidermal split with neutrophilic infiltrates along the dermo-epidermal junction, moderate perivascular, periadnexal and interstitial infiltrates composed of predominantly neutrophils with neutrophilic dusts, lymphocytes, plasma cells, rare eosinophils and increased dermal mucin. Direct immunofluorescence showed strong continuous linear IgG deposits along the basement membrane and weak linear IgM and IgA deposition along the basement membrane zone (BMZ). To our knowledge, this is the first report of vesiculobullous SLE in a Filipino child. This case is a rare form of cutaneous lupus in children. Bullous SLE (BSLE) should be considered in the differential diagnosis of children presenting with generalized bullous eruptions.