Decoded: A Case Report on Dedifferentiated Liposarcoma on the Gluteal Area

  • Juan Paolo David S. Villena Department of Dermatology, Philippine General Hospital, University of the Philippines Manila
  • Eileen Liesl A. Cubillan Department of Dermatology, Philippine General Hospital, University of the Philippines Manila
  • Ann Camille Q. Yuga Department of Dermatology, Philippine General Hospital, University of the Philippines Manila
Keywords: dedifferentiated liposarcoma, immunohistochemistry, MDM2, p16

Abstract

Dedifferentiated liposarcoma is a soft tissue sarcoma of adipocytic lineage. Histopathology and immunohistochemistry are essential for diagnosis. A 51-year-old Filipino woman presented with a rapidly enlarging left gluteal tumor. Histopathology revealed a multilobulated tumor having prominent myxoid stroma with numerous stellate-shaped, atypical cells bearing atypical mitotic figures. Other lobules were composed of sheets of pleomorphic cells, with atypical mitotic figures. The tumor stained positively with alcian blue, vimentin, MDM2 and p16 stains. Other immunohistochemical (IHC) studies done (pancytokeratin, CK7, CK 20, CD 34, CEA, desmin, EMA, SMA, S100) showed negative results. After a 2 cm wide excision of the sarcoma, patient was free from local tumor recurrence for 2 months, after which she was lost to follow-up. We report this case and a brief review of the current literature on dedifferentiated liposarcoma.

Published
2021-08-27

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