Cutaneous Squamous Cell Carcinoma and Multiple Basal Cell Carcinomas in Xeroderma Pigmentosum-Variant Type Treated with Imiquimod 5% Cream and Radiotherapy: A Case Report

Authors

  • Amanda T. Chung, MD-MBA Department of Dermatology, Philippine General Hospital, University of the Philippines Manila https://orcid.org/0009-0002-0163-733X
  • Jerson N. Taguibao, MD-MBA Department of Dermatology, Philippine General Hospital, University of the Philippines Manila https://orcid.org/0009-0006-8690-7560
  • Arunee H. Siripunvarapon, MD Department of Dermatology, Philippine General Hospital, University of the Philippines Manila
  • Ma. Lorna F. Frez, MD Department of Dermatology, Philippine General Hospital, University of the Philippines Manila https://orcid.org/0000-0001-8611-767X

DOI:

https://doi.org/10.47895/amp.v58i17.9208

Keywords:

xeroderma pigmentosum, basal cell carcinoma, squamous cell carcinoma, imiquimod, radiation therapy

Abstract

Xeroderma pigmentosum (XP) is a rare DNA repair disorder characterized by sensitivity to sunlight and predisposition to cutaneous malignancies. There are various types, including the Variant type, which does not manifest with acute sunburn reactions. This results to the development of multiple malignancies that are often discovered at late stages, making management more challenging. This is a case of a 54-year-old Filipino female presenting with multiple basal cell carcinomas (BCCs) on several areas of the face and advanced cutaneous squamous cell carcinoma (cSCC) on the right zygomatic area, treated with imiquimod 5% cream and external beam radiation therapy, respectively. There was an excellent response of the BCCs to imiquimod 5% cream and good tumoral response of the SCC to radiation therapy, with tolerable side effects, highlighting the use of these palliative treatment modalities for XP patients with multiple, unresectable, or difficult-to-treat cutaneous malignancies.

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Published

2024-09-30

How to Cite

1.
Cutaneous Squamous Cell Carcinoma and Multiple Basal Cell Carcinomas in Xeroderma Pigmentosum-Variant Type Treated with Imiquimod 5% Cream and Radiotherapy: A Case Report. Acta Med Philipp [Internet]. 2024 Sep. 30 [cited 2025 Apr. 3];58(17). Available from: https://actamedicaphilippina.upm.edu.ph/index.php/acta/article/view/9208

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