5% Simvastatin Ointment as Treatment for Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects (CHILD) Syndrome in a 4-year-old Female: A Case Report

Authors

  • Denise Marie B. David, MD Department of Dermatology, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines https://orcid.org/0009-0003-5263-6166
  • Koreen Blossom T. Chan, MD Department of Dermatology, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines
  • Carmela Augusta F. Dayrit-Castro, MD Department of Dermatology, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines; Section of Dermatology, De La Salle University Medical Center, Dasmarinas, Cavite, Philippines

DOI:

https://doi.org/10.47895/amp.v58i17.9202

Keywords:

Congenital Hemidysplasia with Ichthyosiform erythroderma and Limb Defects Syndrome, CHILD Syndrome, simvastatin ointment, case report

Abstract

A 4-year-old female with Congenital Hemidysplasia with Ichthyosiform erythroderma and Limb Defects (CHILD) syndrome, with a pathogenic variant of the NSDHL gene, c.130G>A (p.Gly44Ser), and unilateral right-sided erythematous verrucous plaques with scaling and ipsilateral limb defects, was started on 5% simvastatin ointment. It was applied twice daily for four months, with improvement already seen starting week 2. Monotherapy with 5% simvastatin ointment was able to decrease the thickness of the verrucous plaques seen in our patient, highlighting that the accumulation of toxic metabolites may play a more crucial role in its disease pathogenesis.

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Published

2024-09-30

Issue

Vol. 58 No. 17 (2024): Dermatology Issue 3

Section

Articles

How to Cite

1.
5% Simvastatin Ointment as Treatment for Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects (CHILD) Syndrome in a 4-year-old Female: A Case Report. Acta Med Philipp [Internet]. 2024 Sep. 30 [cited 2025 Apr. 3];58(17). Available from: https://actamedicaphilippina.upm.edu.ph/index.php/acta/article/view/9202

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