Combination Doxycycline and Topical Corticosteroids in the Treatment of Ulcerative Pyoderma Gangrenosum: A Case Report

Authors

  • Doha Mae Laurisse M. Manalo-Legas, MD, MPM-HSD Department of Dermatology, Philippine General Hospital, University of the Philippines Manila https://orcid.org/0000-0001-9940-8695
  • Erickah Mary Therese D. Calayag, MD Department of Dermatology, Philippine General Hospital, University of the Philippines Manila
  • Eillen Luisa A. Chen, MD Department of Dermatology, Philippine General Hospital, University of the Philippines Manila

DOI:

https://doi.org/10.47895/amp.v58i17.7462

Keywords:

pyoderma gangrenosum, doxycycline, nonhealing ulcer, neutrophillic dermatosis

Abstract

Pyoderma gangrenosum (PG) is a chronic inflammatory neutrophilic dermatosis often presenting as a solitary enlarging painful ulcer with red to violaceous undermined borders. This report delves into the role of doxycycline in the treatment of PG in a 44-year-old male COVID-19 positive patient who has concomitant active tuberculosis infection and end-stage kidney disease, for which both first-line treatments (systemic corticosteroid and cyclosporine) are contraindicated. After three months on doxycycline and topical corticosteroids, there was resolution of the ulcers and no note of recurrence up to three months from completion of the treatment regimen.

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Published

2024-09-30

Issue

Vol. 58 No. 17 (2024): Dermatology Issue 3

Section

Articles

How to Cite

1.
Combination Doxycycline and Topical Corticosteroids in the Treatment of Ulcerative Pyoderma Gangrenosum: A Case Report. Acta Med Philipp [Internet]. 2024 Sep. 30 [cited 2025 Apr. 24];58(17). Available from: https://actamedicaphilippina.upm.edu.ph/index.php/acta/article/view/7462