Craniorachischisis in a 33-week-old Female Fetus: A Case Report

Authors

  • Clarisse Veronica L. Mirhan, MD Department of Laboratories, Philippine General Hospital, University of the Philippines Manila
  • Cecile C. Dungog, MD, PhD Department of Laboratories, Philippine General Hospital, University of the Philippines Manila
  • Karen Cybelle J. Sotalbo, MD Department of Pathology, College of Medicine, University of the Philippines Manila

DOI:

https://doi.org/10.47895/amp.vi0.6712

Keywords:

autopsy, case report, congenital abnormalities, craniorachischisis, neural tube defects

Abstract

We report the case of a 33-week-old female fetus born with craniorachischisis to a gravida 5, para 4 (3104) mother with no previous history of conceiving a child with a neural tube defect. Craniorachischisis is characterized by anencephaly and an open defect extending from the brain to the spine and is the most severe and fatal type of neural tube defect. Although the cause of neural tube defects is hypothesized to be multifactorial and is usually sporadic, the risk is increased in neonates born to mothers with a family history or a previous pregnancy with neural tube defect, both of which are not present in the index case. This case is unique in that only during the fifth pregnancy did the couple conceive a child with a neural tube defect, emphasizing that folic acid supplementation, the sole preventive measure proven to decrease the risk of neural tube defects, remains to be important in the periconceptual period for all women of childbearing age.

 

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Published

2024-04-15

Issue

Vol. 58 No. 6 (2024)

Section

Articles

How to Cite

1.
Craniorachischisis in a 33-week-old Female Fetus: A Case Report. Acta Med Philipp [Internet]. 2024 Apr. 15 [cited 2025 Apr. 5];58(6). Available from: https://actamedicaphilippina.upm.edu.ph/index.php/acta/article/view/6712

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