Rotor’s Syndrome: A Family Study*

Authors

  • Pio F. Poblete Department of Medicine and Pathology, College of Medicine
  • Milagros Reyes Department of Medicine and Pathology, College of Medicine
  • Lourdes Manahan Department of Medicine and Pathology, College of Medicine
  • Adelaida Dalmacio-Cruz Department of Medicine and Pathology, College of Medicine

DOI:

https://doi.org/10.47895/amp.v56i2.4075

Keywords:

Rotor's Syndrome, hereditary hyperbilirubinemia, Philippines

Abstract

A family was studied in which three members in the sibship belonging to the fourth generation were found to have Rotor’s syndrome. More detailed examinations including blood studies, liver profiles, oral cholecystograms, and liver biopsies where performed on the affected siblings. The results were related to what is at present known about the features and mechanisms of Rotor’s syndrome, pari passu the current concept of bilirubin metabolism. It is suggested that the constant finding, and possibly the only characteristic one in Rotor’s syndrome, is the absence of abnormal hepatic cell pigmentation. Pedigree analysis of the present family shows that the transmission of this disorder may be conditioned by an autosomal recessive gene.

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Published

2022-02-18

How to Cite

1.
Rotor’s Syndrome: A Family Study*. Acta Med Philipp [Internet]. 2022 Feb. 18 [cited 2025 Apr. 5];56(2). Available from: https://actamedicaphilippina.upm.edu.ph/index.php/acta/article/view/4075