Neonatal Cholestasis Secondary to Congenital Syphilis

Authors

  • April P. Padua-Zamora Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, College of Medicine and Philippine General Hospital, University of the Philippines Manila
  • Ma. Patricia Riego de Dios Department of Pediatrics, College of Medicine and Philippine General Hospital, University of the Philippines Manila
  • Germana Emerita V. Gregorio Department of Pediatrics, College of Medicine and Philippine General Hospital, University of the Philippines Manila

DOI:

https://doi.org/10.47895/amp.vi0.3787

Keywords:

Congenital syphilis, neonatal cholestasis, rapid plasma reagin

Abstract

We report two infants with neonatal cholestasis and hepatosplenomegaly secondary to congenital syphilis. The onset of jaundice of the first infant was at six weeks of life and the second case on the 28th hour of life with associated neurologic and bone involvement. The diagnosis was suspected based on a maternal history of untreated syphilis, clinical findings, and a reactive rapid plasma reagin. Early recognition and treatment can lead to clinical improvement but prevention by mandatory testing and treatment of maternal syphilis is a more effective strategy

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Published

2023-01-31

Issue

Vol. 57 No. 1 (2023)

Section

Articles

How to Cite

1.
Neonatal Cholestasis Secondary to Congenital Syphilis. Acta Med Philipp [Internet]. 2023 Jan. 31 [cited 2025 Apr. 18];57(1). Available from: https://actamedicaphilippina.upm.edu.ph/index.php/acta/article/view/3787

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