Unilateral Transcranial Magnetic Resonance-guided Focused Ultrasound Pallidothalamic Tractotomy in X-linked Dystonia-Parkinsonism: A Case Report
DOI:
https://doi.org/10.47895/amp.vi0.3727Keywords:
Abstract
X-linked dystonia-parkinsonism (XDP) is an adult-onset debilitating neurodegenerative disorder presenting with
motor and nonmotor symptoms. The treatment options for XDP are limited. We described a patient with XDP who underwent a unilateral transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) pallidothalamic tractotomy with a one-year follow-up. The patient reported an immediate improvement in his pain after the procedure. Compared to baseline, there was an improvement in his scores in the dystonia (31%), parkinsonism (35.1%), and activities of daily living (71%) subscales at 1-year follow up. The overall improvement at one year was 46%. There were no adverse events noted. Additional studies with larger sample size and follow-up would be needed to document its long-term safety and efficacy.
Author Biographies
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Wei Lin, Department of Neurology, Chang Bing Show Chwan Memorial Hospital, Changhua County, Taiwan
Dr. Lin is with the department of Neurology of Chang Bing Show Chwan Memorial Hospital in Taiwan.
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Kevin Wen-Kai Tsai, MR-guided Focused Ultrasound Center, Chang Bing Show Chwan Memorial Hospital, Changhua County, Taiwan
Dr. Tsai is with the MR-guided Focused Ultrasound Center, Chang Bing Show Chwan Memorial Hospital in Taiwan.
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Hui-Chin Lai, MR-guided Focused Ultrasound Center, Chang Bing Show Chwan Memorial Hospital, Changhua County, Taiwan
Ms. Lai is with the MR-guided Focused Ultrasound Center, Chang Bing Show Chwan Memorial Hospital in Taiwan.
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Pai-Yi Chiu, Department of Neurology, Show Chwan Memorial Hospital, Changhua City, Taiwan
Dr. Chiu is with the Department of Neurology, Show Chwan Memorial Hospital in Taiwan.
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Azalea T. Pajo, Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Philippines
Dr. Pajo is with the Department of Neurosciences, College of Medicine - Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
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Wei-Chieh Chang, Department of Neurosurgery, Chang Bing Show Chwan Memorial Hospital, Changhua County, Taiwan
Dr. Chang is with the Department of Neurosurgery, Chang Bing Show Chwan Memorial Hospita in Taiwan.
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Takaomi Taira, Department of Neurosurgery, Tokyo Women’s Medical University, Tokyo, Japan
Prof. Taira is with the Department of Neurosurgery, Tokyo Women’s Medical University, Tokyo, Japan.