Delayed-type Hypersensitivity Reaction to Glargine and Biphasic Isophane Human Insulin in a Filipino Patient with Type 2 Diabetes Mellitus: A Practical Approach to Diagnosis and Management

Authors

  • Carol Stephanie C. Tan-Lim Division of Allergy and Immunology, Department of Pediatrics, University of the Philippines-Philippine General Hospital
  • Addah S. de Peralta Division of Allergy and Immunology, Department of Pediatrics, University of the Philippines-Philippine General Hospital
  • Alric V. Mondragon Division of Allergy and Immunology, Department of Medicine, University of the Philippines-Philippine General Hospital

DOI:

https://doi.org/10.47895/amp.vi0.3202

Keywords:

drug hypersensitivity, insulin, diabetes mellitus

Abstract

Insulin hypersensitivity reactions are rare, but cause significant complexity in the care of patients with diabetes mellitus. A 54-year-old Filipino male with type 2 diabetes mellitus and multiple co-morbidities developed delayed type hypersensitivity reactions to biphasic isophane human insulin and glargine. Despite good glycemic control on oral hypoglycemic agents, his endocrinologist foresaw the need for future insulin therapy, particularly one basal and one short-acting insulin. Targeted skin tests demonstrated protamine allergy and negative reactions to regular insulin and detemir. Close coordination of care among endocrinologists, allergists, patients and patients’ family is needed to optimize glucose control, prevent complications, and minimize the risk of future hypersensitivity reactions.

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Published

2022-03-03

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Section

Articles

How to Cite

1.
Delayed-type Hypersensitivity Reaction to Glargine and Biphasic Isophane Human Insulin in a Filipino Patient with Type 2 Diabetes Mellitus: A Practical Approach to Diagnosis and Management. Acta Med Philipp [Internet]. 2022 Mar. 3 [cited 2025 Apr. 4];56(3). Available from: https://actamedicaphilippina.upm.edu.ph/index.php/acta/article/view/3202

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