Clinical Profile and Treatment Outcome of Culture-negative Infective Endocarditis in Children at UP-PGH: A Ten-year Retrospective Study

  • Mylah P. Alfeche
  • Ma. Concepcion S. Sison
Keywords: culture-negative endocarditis, children, outcome


Objective. This study determined the demographic data, clinical profile, treatment and outcome of BCN-IE in children at UP-PGH.

Methods. This is a retrospective study of children with BCN-IE admitted at UP-PGH from 2004-2013. Demographic data, clinical presentation, previous antibiotic use, echocardiographic findings, an antibiotic used and outcome of patients were recorded and analyzed. Results in the demographic and clinical profile were expressed as frequencies, percentages and means. To compare the clinical features, echocardiographic findings and antibiotic regimen used as to the outcome, Fischer’s exact test was used.

Results. Among 91 patients diagnosed with infective endocarditis, 61.54% had BCN-IE. The age, gender and clinical presentation were similar to other studies. Clinical presentation and echocardiographic findings did not have influence on outcome of children with BCN-IE. The use of penicillin G and amikacin is associated with unfavorable outcome after 4 weeks or less of administration.

Conclusion. The incidence of BCN-IE is high in UP-PGH. The demographic distribution, clinical and echocardiographic features of patients do not have an influence on the outcome. The trend to the unfavorable outcome with the use of penicillin suggests the need to target fastidious organisms in BCN-IE. Further investigation is warranted to establish the etiologic agents of BCN-IE.