Variants Near CETP, MTTP and BUD13-ZPR1-APOA5 may be Nominally Associated with Poor Statin Response Among Filipinos
DOI:
https://doi.org/10.47895/amp.vi0.2353Keywords:
Abstract
Objective. Several studies showed that genetic factors affect responsiveness to statins among different populations. This study investigated the associations of candidate genetic variants with poor response to statins among Filipinos.
Methods. In this unmatched case-control study, dyslipidemic participants were grouped into statin responders and poor responders based on the degree of reduction in LDL-c from baseline. DNA from blood samples were genotyped and analyzed. The association of candidate variants with statin response was determined using chi-square and logistic regression analysis.
Results. We included 162 adults on statins (30 poor responders as cases, 132 good responders as controls). The following variants are nominally associated with poor response to statin among Filipinos at a per-comparison error rate of 0.05: rs173539 near CETP (OR=3.05, p=0.015), rs1800591 in MTTP (OR=3.07, p=0.021), and rs1558861 near the BUD13-ZPR1-APOA5 region (OR=5.08, p=0.004).
Conclusion. Genetic variants near CETP, MTTP and the BUD13-ZPR1-APOA5 region are associated with poor response to statins among Filipinos. Further study is recommended to test the external validity of the study in the general Filipino population.
Author Biographies
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Lourdes Ella G. Santos, Department of Medicine, University of the Philippines, Philippine General Hospital
Clinical Associated Professor
Division of Adult Cardiology
Philippine General Hospital
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Jose B. Nevado, Jr., Institute of Human Genetics, National Institutes of Health
Research Professor
National Institutes of Health
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Eva Maria C. Cutiongco - de la Paz, National Institutes of Health; Philippine Genome Center
Executive Director
National Institutes of Health
Program Director
Philippine Genome Center
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Lauro L. Abrahan IV, Department of Medicine, University of the Philippines, Philippine General Hospital
Clinical Fellow
Division of Adult Cardiology
Department of Medicine
Philippine General Hospital
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Aimee Yvonne Criselle L. Aman, Institute of Human Genetics, National Institutes of Health
Senior Research Specialist
Institute of Human Genetics
National Institutes of Health
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Elmer Jasper B. Llanes, Department of Medicine, University of the Philippines, Philippine General Hospital
Clinical Associate Professor
Division of Adult Cardiology
Department of Medicine
Philippine General Hospital
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Jose Donato A. Magno, Department of Medicine, University of the Philippines, Philippine General Hospital
Clinical Associate Professor
Division of Adult Cardiology
Department of Medicine
Philippine General Hospital
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Deborah Ignacia D. Ona, Department of Medicine, University of the Philippines, Philippine General Hospital
Clinical Associate Professor
Division of Adult Cardiology
Department of Medicine
Philippine General Hospital
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Felix Eduardo R. Punzalan, Department of Medicine, University of the Philippines, Philippine General Hospital
Medical Specialist
Department of Medicine
Philippine General Hospital
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Paul Ferdinand M. Reganit, Department of Medicine, University of the Philippines, Philippine General Hospital
Clinical Associate Professor
Division of Adult Cardiology
Department of Medicine
Philippine General Hospital
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Richard Henry P. Tiongco II, Department of Medicine, University of the Philippines, Philippine General Hospital
Associate Professor
Department of Medicine
Philippine General Hospital
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Jaime Alfonso M. Aherrera, Department of Medicine, University of the Philippines, Philippine General Hospital
Clinical Fellow
Division of Adult Cardiology
Department of Medicine
Philippine General Hospital
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Charlene F. Agustin, Department of Medicine, University of the Philippines, Philippine General Hospital
Clinical Fellow
Division of Adult Cardiology
Department of Medicine
Philippine General Hospital
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Adrian John P. Bejarin, Institute of Human Genetics, National Institutes of Health
Senior Research Associate
Institute of Human Genetics
Philippine General Hospital
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Rody G. Sy, Department of Medicine, University of the Philippines, Philippine General Hospital
Professor Emeritus
Department of Medicine
Philippine General Hospital