Variants Near CETP, MTTP and BUD13-ZPR1-APOA5 may be Nominally Associated with Poor Statin Response Among Filipinos

  • Lourdes Ella G. Santos Department of Medicine, University of the Philippines, Philippine General Hospital
  • Jose B. Nevado, Jr. Institute of Human Genetics, National Institutes of Health
  • Eva Maria C. Cutiongco - de la Paz National Institutes of Health; Philippine Genome Center
  • Lauro L. Abrahan IV Department of Medicine, University of the Philippines, Philippine General Hospital
  • Aimee Yvonne Criselle L. Aman Institute of Human Genetics, National Institutes of Health
  • Elmer Jasper B. Llanes Department of Medicine, University of the Philippines, Philippine General Hospital
  • Jose Donato A. Magno Department of Medicine, University of the Philippines, Philippine General Hospital
  • Deborah Ignacia D. Ona Department of Medicine, University of the Philippines, Philippine General Hospital
  • Felix Eduardo R. Punzalan Department of Medicine, University of the Philippines, Philippine General Hospital
  • Paul Ferdinand M. Reganit Department of Medicine, University of the Philippines, Philippine General Hospital
  • Richard Henry P. Tiongco II Department of Medicine, University of the Philippines, Philippine General Hospital
  • Jaime Alfonso M. Aherrera Department of Medicine, University of the Philippines, Philippine General Hospital
  • Charlene F. Agustin Department of Medicine, University of the Philippines, Philippine General Hospital
  • Adrian John P. Bejarin Institute of Human Genetics, National Institutes of Health
  • Rody G. Sy Department of Medicine, University of the Philippines, Philippine General Hospital
Keywords: Filipino, BUD13-ZPR1-APOA5, CETP, lipid, MTTP, statin

Abstract

Objective. Several studies showed that genetic factors affect responsiveness to statins among different populations. This study investigated the associations of candidate genetic variants with poor response to statins among Filipinos.

Methods. In this unmatched case-control study, dyslipidemic participants were grouped into statin responders and poor responders based on the degree of reduction in LDL-c from baseline. DNA from blood samples were genotyped and analyzed. The association of candidate variants with statin response was determined using chi-square and logistic regression analysis.

Results. We included 162 adults on statins (30 poor responders as cases, 132 good responders as controls). The following variants are nominally associated with poor response to statin among Filipinos at a per-comparison error rate of 0.05: rs173539 near CETP (OR=3.05, p=0.015), rs1800591 in MTTP (OR=3.07, p=0.021), and rs1558861 near the BUD13-ZPR1-APOA5 region (OR=5.08, p=0.004).

Conclusion. Genetic variants near CETP, MTTP and the BUD13-ZPR1-APOA5 region are associated with poor response to statins among Filipinos. Further study is recommended to test the external validity of the study in the general Filipino population.

Author Biographies

Lourdes Ella G. Santos, Department of Medicine, University of the Philippines, Philippine General Hospital

Clinical Associated Professor

Division of Adult Cardiology

Philippine General Hospital

Jose B. Nevado, Jr., Institute of Human Genetics, National Institutes of Health

Research Professor

National Institutes of Health

Eva Maria C. Cutiongco - de la Paz, National Institutes of Health; Philippine Genome Center

Executive Director

National Institutes of Health

 

Program Director

Philippine Genome Center

Lauro L. Abrahan IV, Department of Medicine, University of the Philippines, Philippine General Hospital

Clinical Fellow

Division of Adult Cardiology

Department of Medicine

Philippine General Hospital

Aimee Yvonne Criselle L. Aman, Institute of Human Genetics, National Institutes of Health

Senior Research Specialist

Institute of Human Genetics

National Institutes of Health

Elmer Jasper B. Llanes, Department of Medicine, University of the Philippines, Philippine General Hospital

Clinical Associate Professor

Division of Adult Cardiology

Department of Medicine

Philippine General Hospital

Jose Donato A. Magno, Department of Medicine, University of the Philippines, Philippine General Hospital

Clinical Associate Professor

Division of Adult Cardiology

Department of Medicine

Philippine General Hospital

Deborah Ignacia D. Ona, Department of Medicine, University of the Philippines, Philippine General Hospital

Clinical Associate Professor

Division of Adult Cardiology

Department of Medicine

Philippine General Hospital

Felix Eduardo R. Punzalan, Department of Medicine, University of the Philippines, Philippine General Hospital

Medical Specialist

Department of Medicine

Philippine General Hospital

Paul Ferdinand M. Reganit, Department of Medicine, University of the Philippines, Philippine General Hospital

Clinical Associate Professor

Division of Adult Cardiology

Department of Medicine

Philippine General Hospital

Richard Henry P. Tiongco II, Department of Medicine, University of the Philippines, Philippine General Hospital

Associate Professor

Department of Medicine

Philippine General Hospital

Jaime Alfonso M. Aherrera, Department of Medicine, University of the Philippines, Philippine General Hospital

Clinical Fellow

Division of Adult Cardiology

Department of Medicine

Philippine General Hospital

Charlene F. Agustin, Department of Medicine, University of the Philippines, Philippine General Hospital

Clinical Fellow

Division of Adult Cardiology

Department of Medicine

Philippine General Hospital

Adrian John P. Bejarin, Institute of Human Genetics, National Institutes of Health

Senior Research Associate

Institute of Human Genetics

Philippine General Hospital

Rody G. Sy, Department of Medicine, University of the Philippines, Philippine General Hospital

Professor Emeritus

Department of Medicine

Philippine General Hospital

Published
2022-06-14
How to Cite
1.
Santos LEG, Nevado, Jr. JB, Cutiongco - de la Paz EMC, Abrahan IV LL, Aman AYCL, Llanes EJB, Magno JDA, Ona DID, Punzalan FER, Reganit PFM, Tiongco II RHP, Aherrera JAM, Agustin CF, Bejarin AJP, Sy RG. Variants Near CETP, MTTP and BUD13-ZPR1-APOA5 may be Nominally Associated with Poor Statin Response Among Filipinos. Acta Med Philipp [Internet]. 2022Jun.14 [cited 2024Mar.29];56(10). Available from: https://actamedicaphilippina.upm.edu.ph/index.php/acta/article/view/2353
Section
Articles

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