Successful Treatment of a Patient with Neuropsychiatric Lupus and Triple Positive Antiphospholipid Syndrome with Chronic Isolated Seizure: A Case Report

Authors

  • Mark Andrian O. Yano, MD Division of Rheumatology, Department of Medicine, Philippine General Hospital, University of the Philippines Manila
  • Evelyn O. Salido, MD, MSc Division of Rheumatology, Department of Medicine, Philippine General Hospital, University of the Philippines Manila

DOI:

https://doi.org/10.47895/amp.vi0.11710

Keywords:

neuropsychiatric lupus, antiphospholipid syndrome, SLE, seizure, case report

Abstract

Neuropsychiatric SLE (NPSLE) comprises the neurologic and psychiatric syndromes observed in patients with SLE after exclusion of other causes. The diagnosis of NPSLE is challenging due to diverse clinical manifestations and absence of laboratory or radiologic biomarkers. 

We present the case of a patient with SLE with a chronic isolated seizure and was successfully managed with antiepileptic medication and high-dose corticosteroids. 

Seizures may occur as an isolated manifestation of an SLE flare. Ischemic and inflammatory causes of seizure may coexist in active lupus and both should be considered in managing patients. A prompt and holistic workup to rule out metabolic, infectious, and structural neural causes and lupus disease activity of seizures is prudent for patients with SLE.

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Published

2025-03-10

Issue

Early Access 2025

Section

Articles

License

Copyright (c) 2025 Acta Medica Philippina

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

1.
Successful Treatment of a Patient with Neuropsychiatric Lupus and Triple Positive Antiphospholipid Syndrome with Chronic Isolated Seizure: A Case Report. Acta Med Philipp [Internet]. 2025 Mar. 10 [cited 2025 Apr. 4];. Available from: https://actamedicaphilippina.upm.edu.ph/index.php/acta/article/view/11710